Rexin-G Controls Tumor Growth and Improves Survival in Chemotherapy-Resistant Soft Tissue Cancers
SAN MARINO, Calif. — Epeius Biotechnologies announced today the results of Phase I/II and II studies of Rexin-G in chemotherapy-resistant metastatic soft tissue sarcoma and osteosarcoma, as presented by Dr. Sant P. Chawla, principal investigator, at the CTOS 14th annual meetings held in London UK on November 13-15, 2008. Patients received repeated infusions of Rexin-G i.v. over a period up to 9 months. Analysis of safety and efficacy data showed no major toxicity, while documenting significant control of tumor growth.
Analysis of efficacy in 42 patients with bone and soft tissue sarcoma showed a dose-response relationship between overall survival and Rexin-G which was highly significant. A confirmatory Phase II study in 17 osteosarcoma patients showed a median overall survival greater than seven months; that is, after failing standard chemotherapies. Two patients are disease-free greater than 6 months after surgical resection of residual tumors and Rexin-G given as both neoadjuvant and adjuvant monotherapy.
These studies indicate that (i) intravenous Rexin-G is safe and well-tolerated, and (ii) Rexin-G controls tumor growth and improves survival in a dose-dependent manner in patients with chemotherapy-resistant metastatic soft tissue sarcoma and osteosarcoma.
About Epeius Biotechnologies
Epeius Biotechnologies Corporation is a privately held biopharmaceutical company dedicated to the advancement of genetic medicine with the development and commercialization of its proprietary targeted delivery systems.
To learn more about Rexin-G and Epeius Biotechnologies’ pipeline of proprietary compounds currently available for clinical development, please visit us at http://www.epeiusbiotech.com .
[tags]Epeius Biotechnologies, Rexin-G genetic medicine, biopharmaceutical company[/tags]
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ABOUT THE EDITOR: Tabitha Angel Berg is an aspiring author and musician and joined eNewsChannels in Nov. 2006 as an editor and mistress of the content management system. She likes ferrets better than cats and tea better than coffee, and is still waiting on the perfect ebook reading device.
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